At the heart of the Audi RS5 Coupe is a 4163 cc normally aspirated V8 engine. The 4.2 FSI produces power output of 450 hp (331 kW) at 8250 rpm with maximum torque of 430 Nm (317.15 lb.-ft.) between 4000 and 6000 rpm. The engine accelerates the RS5 Coupe from 0-100 km/h (62.14 mph) in 4.6 seconds. Like all RS models, the Audi RS5 Coupe also applies the power to the road with Quattro permanent all-wheel drive.

The RS5 Coupe sits on 19-inch forged aluminum wheels with 265/35-series tires that are standard and optional 20-inch wheels with 275/30-series for the high-performance coupe. The brake system of the Audi RS Coupé features large, internally ventilated wave brake discs, with the front discs measuring 365 millimeters (14.37 in) in diameter. The steel friction rings with their wave-like outer contour are perforated and connected to the aluminum brake caps via pins. This direct structure reduces tensions, quickly dissipates the heat and prevents the transmission of temperature peaks. Moreover, the redesigned shape of the friction rings results in three kilograms (6.61 lb) of weight being saved in total, thus improving the balance of unsprung masses.

Outside, the Audi RS5 features new single-frame grille with beveled upper corners features a high-gloss, anthracite gray honeycomb structure and a matt aluminum-look frame. The standard xenon plus headlights are framed by narrow strips of LED daytime running lights. The air flows through large openings embedded in a distinctive bumper featuring a splitter edge like on a racing car. Sharper edges make the engine hood appear more three-dimensional so that the Audi RS5 looks even lower and wider when viewed from the front. The Audi RS5 Coupé is 23 millimeters (0.91 in) longer and six millimeters (0.24 in) wider than the Audi A5 Coupé, but six millimeters (0.24 in) lower. Eight exterior colors are available, from solid, metallic and pearl effect finishes to a specially pigmented crystal effect paint.

For the interior the Audi RS5 Coupe comes with the standard sport seats with integrated headrests. Also offered is seat upholstery in Fine Nappa leather with black or lunar silver color choices. The interior of the Audi RS5 is bathed in black, with narrow chrome clasps at the switches and control elements.